Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.
reduced OA tolerance. Our identification of genes contributing to OA resistance in laboratory and natural contexts demonstrates how complementary selection approaches can provide insights into complex mechanisms of toxin susceptibility and adaptation. Such methods could have practical applications in the characterization of natural and artificial insecticides.
Authors
- Raghuvir Viswanatha (ORCID: https://orcid.org/0000-0002-9457-6953)
- Camilla Roselli (ORCID: https://orcid.org/0000-0002-2272-980X)
- Steeve Cruchet (ORCID: https://orcid.org/0000-0001-7796-6151)
- Matthew Butnaru
- Srishti Goswami
- Dafni Hadjieconomou
- Joydeep De (ORCID: https://orcid.org/0000-0001-9467-5479)
- Michele Marconcini (ORCID: https://orcid.org/0000-0002-6785-9106)
- Stephanie E. Mohr (ORCID: https://orcid.org/0000-0001-9639-7708)
- Richard Benton
- Norbert Perrimon
Institutions
- Centre National de la Recherche Scientifique (FR)
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Inserm (FR)
- Sorbonne Université (FR)
- Boston VA Research Institute (US)
- Institut du Cerveau (FR)
- University of Lausanne (CH)
Publication Details
- Journal
- PubMed
- Published
- 2026-09-11
- DOI
- https://doi.org/10.7554/elife.111773
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00