In the Search for Suicide Signatures, Phenotype Matters
We read with interest the meta-analysis by Sokolov, Lafta et al. [ 1 ] investigating transcriptomic alterations in confirmed suicide cases, primarily in the dorsolateral prefrontal cortex (DLPFC). We commend the authors for their effort integrating 16 cohorts to identify differentially expressed genes, among which were the markers P2RY12 and CX3CR1 in all brain regions and in the DLPFC.
Authors
- Giovanna Punzi (ORCID: https://orcid.org/0000-0001-7530-3880)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Lieber Institute for Brain Development (US)
Publication Details
- Journal
- Translational Psychiatry
- Published
- 2026-07-02
- DOI
- https://doi.org/10.1038/s41398-026-04227-8
- Primary Topic
- Suicide and Self-Harm Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00