Phenanthrenoids and oxoaporphine alkaloids from <i>Monoon fuscum</i> B. Xue & R.M.K. Saunders and their biological activities
Phytochemical investigation of the twigs of Monoon fuscum (Annonaceae) led to the isolation and characterisation of eight compounds, including a new phenanthrenoid, 2-(2-hydroxy-3,6,7-trimethoxyphenanthren-1-yl)ethyl acetate (1), together with seven known compounds (2–8). The structure of the new compound was elucidated through extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS. All compounds were evaluated for the nitric oxide (NO) production inhibitory activity in LPS-induced RAW 264.7 cells and cytotoxicity against the colorectal (SW-480) cancer cell line. Oxostephanine (4), oxostephanosine (5), and (–)-oxoisocorypalmine (8) exhibited moderate inhibitory effects on NO production in LPS-induced RAW 264.7 cells with IC50 >2 µM. Perakensol (2) exhibited the strongest cytotoxicity against SW-480 cells with an IC50 value of 392.30 ± 70.59 µM. Notably, new compound 1 demonstrated the highest selectivity (SI = 2.18) towards cancer cells over normal colon epithelial (CCD-841 CoN) cells.
Authors
- Passakorn Teerapongpisan
- Siripat Aluksanasuwan (ORCID: https://orcid.org/0000-0002-3542-5880)
- Phateep Hankittichai (ORCID: https://orcid.org/0000-0002-3777-0848)
- Phunrawie Promnart (ORCID: https://orcid.org/0009-0005-7741-5567)
- Surat Laphookhieo (ORCID: https://orcid.org/0000-0002-4757-2781)
- Sorraya Champakam (ORCID: https://orcid.org/0000-0001-5161-8458)
- Atthapan Morchang (ORCID: https://orcid.org/0000-0001-9076-7886)
- Sarot Cheenpracha (ORCID: https://orcid.org/0000-0002-4333-1059)
- Keerakarn Somsuan (ORCID: https://orcid.org/0000-0002-9848-8010)
- Siau Hui Mah (ORCID: https://orcid.org/0000-0003-0370-4866)
- Panupong Puttarak (ORCID: https://orcid.org/0000-0003-2534-5956)
- Panom Winyayong
Institutions
- Prince of Songkla University (TH)
- Mae Fah Luang University (TH)
- University of Phayao (TH)
- Taylor's University (MY)
- Pharmac (NZ)
- Walailak University (TH)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-06-30
- DOI
- https://doi.org/10.1080/14786419.2026.2694080
- Primary Topic
- Phytochemistry and biological activities of Ficus species
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Thailand