Photothermal Pulse Output-Nanomachines for Enhanced Cuproptosis in Tumor Cells
Cu@MSNs@ICG nanomachines possess a unique architecture featuring copper deposited on mesoporous silica nanoparticles (MSNs) with indocyanine green (ICG) modification, enabling excellent photothermal pulse output under NIR-II irradiation. Upon 1064 nm illumination, these nanomachines undergo directional self-thermophoretic motion. In the tumor cell microenvironment, the photothermal pulse output drives self-thermophoretic locomotion, simultaneously facilitating photothermal therapy and cuproptosis. This biocompatible, photothermally activated nanomachine system offers a promising platform for synergistic tumor cell therapy.
Authors
- Fei Tong (ORCID: https://orcid.org/0000-0001-6600-9778)
- Yan Dong (ORCID: https://orcid.org/0000-0003-2654-5191)
- Rui Gao (ORCID: https://orcid.org/0000-0003-0021-3527)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-0545-1110)
- Yongsheng Du
- Weiwei Qiao
- Luzhe Zhang
- Zirui Zhang
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Shandong Academy of Pharmaceutical Sciences (CN)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-06-30
- DOI
- https://doi.org/10.1021/acsabm.6c00059
- Primary Topic
- Gold and Silver Nanoparticles Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00