Emergence of invasive <i>Escherichia coli</i> pathobionts in gut microbiome promotes cancer stemness via targeting Hippo pathways
mutation drives the expansion of invasive pathobionts to promote cancer stemness via a VGLL3/TEAD4/CD44 axis. Bacteria-targeting interventions could be an alternative strategy for patients with hereditary tumors.
Authors
- Chung‐Yen Huang (ORCID: https://orcid.org/0000-0001-9691-9537)
- Yi-Hsuan Li (ORCID: https://orcid.org/0000-0003-3530-8454)
- Linda Chia‐Hui Yu (ORCID: https://orcid.org/0000-0003-1461-3249)
- Y H Pai
- You‐Tzung Chen (ORCID: https://orcid.org/0000-0001-6510-3420)
- Yen‐Hsuan Ni (ORCID: https://orcid.org/0000-0002-1158-5249)
- Been‐Ren Lin (ORCID: https://orcid.org/0000-0001-8354-1758)
- Liang‐Chuan Lai (ORCID: https://orcid.org/0000-0002-3913-5338)
- Yu-Chien Liao
- Y S Jeng
- S C Wei
- Chia-Hsien Lin
- Yu-Wen Peng
- Pei-Tzu Hu
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Gut Microbes
- Published
- 2026-06-30
- DOI
- https://doi.org/10.1080/19490976.2026.2694795
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Health Research Institutes
- National Science and Technology Council