Peri-operative nutrition in femoral neck fracture arthroplasty: a pragmatic framework to mitigate dual-hit catabolism and improve outcomes

Femoral neck fracture patients represent one of the most metabolically vulnerable populations undergoing total hip arthroplasty, with malnutrition prevalence frequently exceeding 40–50%. • Acute trauma, enforced fasting, inflammation and comorbidity amplify the surgical stress response, accelerating protein catabolism, immune dysfunction and muscle loss. • Malnutrition in femoral neck fracture patients is independently associated with increased mortality, infection, prolonged hospital stay, delayed mobilisation and institutionalisation. • Unlike elective arthroplasty, opportunities for pre-operative optimisation are limited, making early identification and aggressive peri-operative nutritional support critical. • A phase-specific nutritional framework—focused on rapid screening, intra-operative metabolic protection and early post-operative feeding—offers a pragmatic, low-cost strategy to improve outcomes, particularly in LMIC settings.

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Publication Details

Journal
Orthopedic Reviews
Published
2026-06-30
DOI
https://doi.org/10.52965/001c.163301
Primary Topic
Nutrition and Health in Aging
Type
article
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article

Peri-operative nutrition in femoral neck fracture arthroplasty: a pragmatic framework to mitigate dual-hit catabolism and improve outcomes

Winifred Mukiibi, Nkhodiseni Sikhauli, Dyllan Brett Geldenhuys, Leonard Muhango et al.
Orthopedic Reviews
Nutrition and Health in Aging
article

Peri-operative nutrition in femoral neck fracture arthroplasty: a pragmatic framework to mitigate dual-hit catabolism and improve outcomes

Winifred Mukiibi, Nkhodiseni Sikhauli, Dyllan Brett Geldenhuys, Leonard Muhango, J R T Pietrzak, Nena Elebo
article en

Abstract

Femoral neck fracture patients represent one of the most metabolically vulnerable populations undergoing total hip arthroplasty, with malnutrition prevalence frequently exceeding 40–50%. • Acute trauma, enforced fasting, inflammation and comorbidity amplify the surgical stress response, accelerating protein catabolism, immune dysfunction and muscle loss. • Malnutrition in femoral neck fracture patients is independently associated with increased mortality, infection, prolonged hospital stay, delayed mobilisation and institutionalisation. • Unlike elective arthroplasty, opportunities for pre-operative optimisation are limited, making early identification and aggressive peri-operative nutritional support critical. • A phase-specific nutritional framework—focused on rapid screening, intra-operative metabolic protection and early post-operative feeding—offers a pragmatic, low-cost strategy to improve outcomes, particularly in LMIC settings.

Orthopedic ReviewsVol. 18
University of the Witwatersrand (ZA)
Zero hunger
Openalex Percentile: Top 8%
Nutrition and Health in Aging
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