What makes a good diagnostic tool: An elicitation using a Multi-Criteria Decision Analysis framework

Diagnostic tools are essential to health-related decision-making for animals, humans and the environment. However, defining what constitutes a good diagnostic remains challenging. This study applied a Multi-Criteria Decision Analysis (MCDA) framework to identify and weight key attributes of diagnostic tools for infectious diseases. A workshop conducted as part of the EU Partnership on Animal Health and Welfare (EU PAHW), engaging experts to define, discuss, and score evaluation criteria. Six core criteria were identified: Performance, Data Interpretation, Cost, Speed/Timeliness, Ease of Testing, and Generality. Performance was rated as the most important attribute, followed by Data Interpretation and Cost. These findings provide an evidence-based framework for assessing diagnostics and prioritising development efforts, and the approach can support One Health strategies for improving diagnostic accessibility and effectiveness.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-06-30
DOI
https://doi.org/10.5281/zenodo.21066420
Primary Topic
Zoonotic diseases and public health
Type
preprint

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preprint

What makes a good diagnostic tool: An elicitation using a Multi-Criteria Decision Analysis framework

Mahbod Entezami, Pikka Jokelainen, Jo Widdicombe, Roberto Marcello La Ragione et al.
Zenodo (CERN European Organization for Nuclear Research)
Zoonotic diseases and public health
preprint

What makes a good diagnostic tool: An elicitation using a Multi-Criteria Decision Analysis framework

Mahbod Entezami, Pikka Jokelainen, Jo Widdicombe, Roberto Marcello La Ragione, Anne Sofie Hammer, Ana Cristina Ferreira, Joaquín M. Prada, Anna K. Fotaki
preprint en

Abstract

Diagnostic tools are essential to health-related decision-making for animals, humans and the environment. However, defining what constitutes a good diagnostic remains challenging. This study applied a Multi-Criteria Decision Analysis (MCDA) framework to identify and weight key attributes of diagnostic tools for infectious diseases. A workshop conducted as part of the EU Partnership on Animal Health and Welfare (EU PAHW), engaging experts to define, discuss, and score evaluation criteria. Six core criteria were identified: Performance, Data Interpretation, Cost, Speed/Timeliness, Ease of Testing, and Generality. Performance was rated as the most important attribute, followed by Data Interpretation and Cost. These findings provide an evidence-based framework for assessing diagnostics and prioritising development efforts, and the approach can support One Health strategies for improving diagnostic accessibility and effectiveness.

Zenodo (CERN European Organization for Nuclear Research)
Statens Serum Institut (DK), University of Copenhagen (DK), University of Helsinki (FI), Estonian University of Life Sciences (EE), University of Surrey (GB), Instituto Nacional de Investigação Agrária e Veterinária (PT)
European Commission
Partnerships for the goals
Zoonotic diseases and public health
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