Dual Nickel/Photoredox-Catalyzed Radical Phosphonylacylation of Terminal Alkenes with Aroyl Chlorides and <i>H</i> -Phosphine Oxides
We report a dual nickel/photoredox-catalyzed three-component phosphonylacylation of various alkenes using readily accessible substrates and commercially available catalysts, delivering structurally diverse γ-ketophosphine oxides in one pot through concurrent C-P/C-C bond formation. This operationally simple strategy also provides efficient access to natural molecule- and pharmaceutical-containing γ-ketophosphine oxide analogues and features mild reaction conditions, a broad substrate scope, high regioselectivity, and moderate to excellent yields.
Authors
- Guo Tang (ORCID: https://orcid.org/0000-0002-4349-398X)
- Yuxing Gao (ORCID: https://orcid.org/0000-0002-6420-0656)
- Hao Zeng (ORCID: https://orcid.org/0009-0006-9034-0456)
- Yufen Zhao (ORCID: https://orcid.org/0000-0002-8513-1354)
- 王卓红
- Wensheng Chen (ORCID: https://orcid.org/0000-0002-8496-7870)
- Pengxiang Xu (ORCID: https://orcid.org/0000-0002-2273-1504)
- Zhongshuo Zheng
Institutions
- Xiamen University (CN)
- Hunan Nonferrous Metal Research Institute (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-06-30
- DOI
- https://doi.org/10.1021/acs.orglett.6c02021
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities