TRPV4 Activation Promotes Hair Growth via TSLP Signaling in the Skin

mice, whereas TRPV4 activation did not, supporting the notion that TSLP acts downstream of TRPV4. In contrast, activation of TRPV3, another TRP channel abundantly expressed in the skin, did not significantly affect hair growth, highlighting the specific role of TRPV4 in this process. Overall, these findings identify a TRPV4-TSLP signaling axis that promotes hair growth and regulates hair follicle function, suggesting a potential therapeutic target for hair loss disorders.