Antiproliferative activity of silver nanoparticles synthesized from Salvia aethiopis

Nanotechnology has emerged as a rapidly developing field of science in recent years. It is used in fields such as agriculture, pharmaceuticals, electronics, and food. Plants exhibit broad-spectrum bioactivity due to their bioactive compound contents and are widely and effectively used in the pharmaceutical and food industries. In this study, the antiproliferative activity of the extract and silver nanoparticles (AgNPs) was evaluated using the human colorectal adenocarcinoma cell line (Caco-2), the human pancreatic adenocarcinoma cell line (Capan-1), and the mouse fibroblast cell line (L929) via MTT assay. In Caco-2 cell lines, cell viabilities were reported to be 27.5±0.7% and 36.8±1.7% after treatment with nanoparticles and the extract, respectively, at a 1.0 µg/mL concentration. In Capan-1 cell lines, the viabilities were determined to be 30.3±1.1% and 46.3±0.5% after treatment with AgNPs and the extract at 1.0 µg/mL, respectively.