SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2
SGLT2 inhibitors boost ketone production by directly activating a liver enzyme, revealing a new mechanism that may contribute to their heart and kidney benefits.
Authors
- Sora Kwon (ORCID: https://orcid.org/0000-0002-8185-8249)
- Kyoung-Han Kim (ORCID: https://orcid.org/0000-0002-0433-656X)
- RAMI AL BATRAN
- Jiaheng Guan (ORCID: https://orcid.org/0000-0003-1765-4476)
- Parisa Pourfarziani
- Xiaobei Li (ORCID: https://orcid.org/0000-0003-2913-6895)
- Abdualrahman Mohammed Abdualkader (ORCID: https://orcid.org/0000-0001-8081-9988)
- Chenhao Bai (ORCID: https://orcid.org/0000-0003-3226-0176)
- Yiming Yin
Institutions
- University of Ottawa (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2026-06-30
- DOI
- https://doi.org/10.1172/jci192333
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research