18F-MFBG Uptake From Multiple Focal “Hot Spots” to Superscan in a Pediatric Patient With High-risk Neuroblastoma
A 5-year-old girl diagnosed with high-risk neuroblastoma enrolled in our clinical trial underwent 18F-MFBG PET/CT, showing multiple discrete focal "hot spots." Bone marrow aspiration confirmed metastatic neuroblastoma involvement. After 5 cycles of immunotherapy and chemotherapy, follow-up 18F-MFBG PET/CT revealed a marked shift in biodistribution: the multiple discrete focal "hot spots" pattern resolved, and diffuse and intense skeletal tracer uptake-consistent with a superscan pattern emerged-including both newly developed lesions-indicative of progressive disease. The present case showed the temporal evolution of 18F-MFBG uptake from multiple focal "hot spots" to a superscan.
Authors
- X W Wang
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
- Cinian Lv
- Keyu Zhang
- Bingyan Zhang
Institutions
- Beijing Automation Control Equipment Institute (CN)
- Institut de Recherche en Santé Digestive (FR)
- Beijing Friendship Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2026-06-29
- DOI
- https://doi.org/10.1097/rlu.0000000000006542
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00