Nickel-Catalyzed 8-Endo Cyclization/Carbonylation for the Synthesis of Eight-Membered Lactams
Medium-sized lactams are prevalent motifs in many bioactive molecules and natural products. However, their construction remains challenging due to unfavorable enthalpic and entropic barriers during the transition state. Herein, a novel nickel-catalyzed 8-endo cyclization/carbonylation has been achieved for the synthesis of eight-membered lactams bearing a gem-difluoro group. This approach features high regioselectivity, good functional group tolerance, and CO gas-free operation, which provides a good supplement for the preparation of eight-membered lactams via a nickel-catalyzed carbonylation process.
Authors
- Xiao‐Feng Wu (ORCID: https://orcid.org/0000-0001-6622-3328)
- Zilin Huang (ORCID: https://orcid.org/0009-0003-7369-2917)
- Yuting Jiang (ORCID: https://orcid.org/0000-0002-0400-6042)
- Hucheng Ma
- Yibin He
- Xinxin Qi
Institutions
- Zhejiang Sci-Tech University (CN)
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Leibniz Institute for Catalysis (DE)
- Ingenierie des Materiaux polymeres (FR)
- Dalian National Laboratory for Clean Energy (CN)
- Interface (United Kingdom) (GB)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-06-29
- DOI
- https://doi.org/10.1021/acs.orglett.6c02643
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences