The Mitochondrial Calcium Uniporter: From Parts to Signaling Networks

fluxes and revealed its pivotal role in health and disease. Here, we retrace the trajectory of the field from the pioneering observations of the 1960s to the molecular era of the MCUC, emphasizing the latest advances in its regulation, integration into cellular networks, and pharmacological targeting.

Authors

Margarita Chudenkova
Fabiana Perocchi (ORCID: https://orcid.org/0000-0002-1102-6500)
Hilda Delgado de la Herran
Michael Feng

Institutions

Helmholtz Zentrum München (DE)
Munich Cluster for Systems Neurology (DE)
Technical University of Munich (DE)
Ludwig-Maximilians-Universität München (DE)

Publication Details

Journal: Cold Spring Harbor Perspectives in Biology
Published: 2026-06-29
DOI: https://doi.org/10.1101/cshperspect.a041770
Primary Topic: Mitochondrial Function and Pathology
Type: preprint

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preprint

The Mitochondrial Calcium Uniporter: From Parts to Signaling Networks

Margarita Chudenkova, Fabiana Perocchi, Hilda Delgado de la Herran, Michael Feng

Jun 29, 2026

Cold Spring Harbor Perspectives in Biology

Mitochondrial Function and Pathology

preprint

The Mitochondrial Calcium Uniporter: From Parts to Signaling Networks

Margarita Chudenkova, Fabiana Perocchi, Hilda Delgado de la Herran, Michael Feng

June 29, 2026preprint en

Abstract

fluxes and revealed its pivotal role in health and disease. Here, we retrace the trajectory of the field from the pioneering observations of the 1960s to the molecular era of the MCUC, emphasizing the latest advances in its regulation, integration into cellular networks, and pharmacological targeting.

Cold Spring Harbor Perspectives in Biology

Helmholtz Zentrum München (DE), Munich Cluster for Systems Neurology (DE), Technical University of Munich (DE), Ludwig-Maximilians-Universität München (DE)

Mitochondrial Function and Pathology

DOI Source OpenAlex

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