10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the “Ceiling Efficacy Effect” of Modern Antifungals?
Given competing death causalities among hematological malignancy patients with invasive aspergillosis (IA), we assessed IA-attributable, contributable, and all-cause mortalities in patients with culture-confirmed IA. Although attributable mortality decreased, contributable and all-cause mortalities remained high. Our data suggest that improving survival would require host augmentation, in addition to improved antifungals.
Authors
- Takahiro Matsuo (ORCID: https://orcid.org/0000-0001-9389-0628)
- Ariel D. Szvalb (ORCID: https://orcid.org/0000-0002-4097-2571)
- Adam G. Stewart (ORCID: https://orcid.org/0000-0002-7262-7529)
- Teny Mathew John (ORCID: https://orcid.org/0000-0002-2675-1529)
- Sebastian Wurster (ORCID: https://orcid.org/0000-0002-7784-7256)
- Dimitrios P. Kontoyiannis (ORCID: https://orcid.org/0000-0002-8051-2940)
- Sung‐Yeon Cho (ORCID: https://orcid.org/0000-0001-5392-3405)
- Yan Jiang (ORCID: https://orcid.org/0009-0006-1219-7770)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2026-06-29
- DOI
- https://doi.org/10.1093/cid/ciag393
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00