ASSESSMENT OF CLINICAL-LABORATORY CHANGES IN ORAL HEALTH INDICATORS IN PATIENTS WITH HAEMOPHILIA AGAINST THE BACKGROUND OF THE USE OF NEW THERAPEUTIC AND PREVENTIVE DENTAL PASTE

Young haemophilia patients with a high incidence of caries, hard tooth tissue lesions, and gingival inflammation are prone to fear of bleeding during individual oral hygiene. This reduces hygiene effectiveness and results in unsatisfactory oral status, necessitating the development of specialised hygiene products. Subject. Toothpaste containing a special dye to improve cleaning quality and components aimed at reducing bleeding and inflammation. Objective. To evaluate the clinical and laboratory effectiveness of a new toothpaste used within a comprehensive dental protocol and its impact on oral tissues in young haemophilia patients. Methodology. An open controlled study was conducted. Subjects were divided into two parallel groups using stratified randomisation and pairwise matching. The observation group included 18 haemophilia patients aged 18-35 years who used an improved toothpaste (patented formulation). The comparison group comprised 18 individuals of the same age and gender with the same diagnosis who received a standard protocol approved by the Russian Dental Association. Assessed parameters: OHI-S index, SBI index, PMA index, mixed saliva pH, secretion rate, and viscosity. Measurements were taken at baseline, after 3 and 6 months. Statistical processing used Statistica version 10.0. Results. By the third month, use of the improved toothpaste in young haemophilia patients was associated with positive dynamics of OHI-S, SBI, and PMA indices regardless of disease severity. Additionally, pH shifted toward physiological values, saliva secretion rate increased, and viscosity decreased. No such changes occurred in the comparison group. Conclusion. Inclusion of the improved toothpaste in a prophylactic and therapeutic protocol for haemophilia patients aged 18–35 years achieves satisfactory or good oral hygiene, significant reduction of gingival bleeding, and decreased inflammation severity. Normalisation of mixed saliva (pH stabilization, increased secretion rate, reduced viscosity) was also observed. The most pronounced positive dynamics were noted in patients with more severe disease, making this approach particularly relevant.