Surgical Outcomes in Perforated vs. Non-Perforated Colon Cancer: A Comparative Retrospective Study

Background: Colorectal cancer (CRC) remains a significant global health challenge, particularly because of its associated complications. Among these, tumor perforation is a critical event linked to increased postoperative morbidity and mortality. This study aimed to evaluate and compare the surgical outcomes of patients with perforated colon cancer versus those with non-perforated colon cancer. Methods: A retrospective comparative study was conducted in the visceral surgery departments of Hassan II University Hospital in Fes, Morocco, including 198 patients who underwent surgical treatment for colon cancer between January 2014 and December 2022. Statistical analyses included descriptive assessments and comparative tests using the Chi-square and Student’s t-tests, with a p-value < 0.05 considered statistically significant. Results: Of the 198 patients, 22 (11%) presented with perforated colon cancer. Laparotomy was the predominant surgical approach in the perforated group (86.4%), whereas laparoscopy was more frequently used in non-perforated cases (56.2%, p = 0.001). Stoma creation was significantly more common in perforated cases (72.7% vs. 4%, p < 0.001), with a notably higher rate of stoma closure failure in the perforated group (37.5% vs. 0%, p < 0.001). Postoperative complications were also more frequent in the perforated group (36.4% vs. 13.6%, p = 0.006), with higher rates of R2 resections (27.3% vs. 0.6%, p < 0.001) and tumor recurrence (27.3% vs. 4.5%, p < 0.001). The mean hospital stay was significantly longer in patients with perforated cancer (11 days vs. 5 days, p < 0.001). Conclusions: This comparative study demonstrates that patients with perforated colon cancer are more likely to require a Hartmann’s procedure, to have prolonged intensive care unit stays, to experience higher rates of postoperative complications, to undergo R2 resections, and to have a greater incidence of tumor recurrence. A non-significant trend toward higher 30-day mortality was also observed.