Diminishing Returns of Novel Autoantibody Discovery in Encephalitis

This Viewpoint describes a plateau in the discovery of clinically meaningful autoantibodies in autoimmune encephalitis (AE) and suggests efforts that are likely to offer greater benefits to patients living with AE.

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Publication Details

Journal
JAMA Neurology
Published
2026-06-29
DOI
https://doi.org/10.1001/jamaneurol.2026.1659
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Diminishing Returns of Novel Autoantibody Discovery in Encephalitis

Frank Leypoldt, Sarosh R. Irani, Naoki Takegami, Gregory S. Day
JAMA Neurology
Autoimmune Neurological Disorders and Treatments
article

Diminishing Returns of Novel Autoantibody Discovery in Encephalitis

Frank Leypoldt, Sarosh R. Irani, Naoki Takegami, Gregory S. Day
article en

Abstract

This Viewpoint describes a plateau in the discovery of clinically meaningful autoantibodies in autoimmune encephalitis (AE) and suggests efforts that are likely to offer greater benefits to patients living with AE.

JAMA Neurology
Jacksonville College (US), University of Oxford (GB), University Hospital Schleswig-Holstein (DE), Mayo Clinic in Florida (US), University of Lübeck (DE)
Zero hunger
Openalex Percentile: Top 7%
Autoimmune Neurological Disorders and Treatments
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