Upregulated CircRNAs With Efficacy in Preclinical <i>In Vivo</i> Models Reveal New Targets for Therapeutic Intervention in Glioma

<h3>Abstract</h3> There is a significant need to improve treatment efficacy for patients with glioma. Therefore, we have analyzed the literature for the role of circular RNAs (circRNAs) with respect to selected pathology-related topics of glioma. We have focused on upregulated circRNAs with efficacy in preclinical <i>in vivo</i> models. The identified circRNAs cover the following topics: Temozolomide (TMZ) resistance, transmembrane and secreted proteins, wingless-related integration site (WNT) signaling, cytoskeleton dynamics, cell-cell and cell-extracellular matrix interactions, as well as circRNAs with additional functions. We describe possible therapeutic tools and challenges with respect to delivery of the corresponding inhibitory agents.