SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL IMIDAZOQUINAZOLINONE DERIVATIVES AS HDAC6 ISOFORM-SELECTIVE INHIBITORS
Synthesis and SAR of Isoform selective HDAC6 inhibitors of novel imidazoquinazolinones is shown. It demonstrates HDAC6 selective pharmacokinetic properties and has clean off-target profile. It shows efficacy comparable to approved HDAC inhibitors.
Authors
- Abhijit Roychowdhury
- Srinivas Gullapalli
- Krishna Anand Putta
- Kaivalya G. Kulkarni (ORCID: https://orcid.org/0009-0006-6687-9902)
- Pankaj Kumar Singh (ORCID: https://orcid.org/0000-0002-4774-6358)
- Tushar Khaladkar
- Dhananjay Magar
- Jayanarayan Kulathingal
- Kailas Shikhare
- Rammohana Reddy Lekkala
Institutions
- Emcure Pharmaceuticals (India) (IN)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2026-06-29
- DOI
- https://doi.org/10.5281/zenodo.21033572
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00