Retrospective Evaluation of the Relationship Between the Systemic Inflammation Index, Left Ventricular Functions, and Prevalence of Coronary Artery Disease in Patients with Chronic Atrial Fibrillation

Objective: The relationship between ‘atrial fibrillation (AF)’ and ‘coronary artery disease (CAD)’ has been identified, and they share a vast array of overlapping risk determinants. Inflammation is of paramount importance in the occurrence and spread of both AF and CAD. The objective of the present study was to clarify the relationship between the level of the ‘systemic inflammation index (SII)’ and ‘left ventricular functions’ and the prevalence of CAD in patients with chronic AF. Methods: The research was conducted using records of 271 patients diagnosed with chronic AF and 301 patients with sinus rhythm in the cardiology outpatient clinic of a university hospital. Patients’ socio-demographic data, comorbidities, laboratory results, echocardiographies, and coronary angiography were evaluated. ‘NLR (neutrophil-lymphocyte ratio),’ ‘PLR (platelet-lymphocyte ratio),’ and ‘LMR (lymphocyte-monocyte ratio)’ were computed using hemogram and biochemistry results. Results: Increased ‘uric acid,’ ‘C-reactive protein,’ and ‘left atrial diameter’ were associated with an increased likelihood of AF. Increased uric acid and SII were associated with an increased risk of having a SYNTAX score ≥23. In the mortality follow-up of the AF group, an increased NLR was associated with an increased probability of mortality. Additionally, whereas a positive correlation was identified between the ‘left ventricular end-diastolic diameter’ and ‘left ventricular end-systolic diameter’ and SII, NLR, and PLR, a negative correlation with LMR was found (p