The Exploration of TPhos as a Monodentate P-Ligand for Palladium-Catalyzed Regioselective Hydrothiocarbonylation of Styrenes under Neutral Conditions
A palladium-catalyzed nonacidic hydrothiocarbonylation of styrenes with CO and thiols has been developed. Utilizing a cyclopropane-based monophosphine ligand (TPhos), this protocol enables the efficient and branched-selective synthesis of alkyl thioesters under mild and neutral conditions with broad substrate scope and excellent functional group tolerance.
Authors
- Xiao‐Feng Wu (ORCID: https://orcid.org/0000-0001-6622-3328)
- Wen Che (ORCID: https://orcid.org/0009-0004-8912-6423)
- Shou‐Fei Zhu (ORCID: https://orcid.org/0000-0002-6055-3139)
- Chang-Sheng Kuai
Institutions
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Nankai University (CN)
- Leibniz Institute for Catalysis (DE)
- Institute of Organic Chemistry (HU)
- Dalian National Laboratory for Clean Energy (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-06-29
- DOI
- https://doi.org/10.1021/acs.orglett.6c02424
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences