Nanotechnology in Food Packaging: Enhancing Safety and Shelf‐Life Through Intelligent and Antimicrobial Systems

ABSTRACT Nanotechnology is transforming food packaging from passive containment systems into intelligent and active platforms capable of enhancing food safety, preserving product quality, and reducing global food losses. This review critically examines recent advances in nanotechnology‐based food packaging, focusing on intelligent nanosensors, antimicrobial nanomaterials, and nano‐enabled barrier systems that improve shelf life, microbial control, and real‐time quality monitoring. Advanced fabrication technologies such as electrospinning, nanoencapsulation, melt extrusion, and biodegradable nanocomposites have improved the scalability, sensitivity, and functionality of modern packaging systems. Embedded nanosensors can detect pH changes, gas production, temperature fluctuations, and microbial spoilage, supporting predictive supply‐chain management and food waste reduction. Antimicrobial nanoparticles and nanocomposites improve barrier performance while actively inhibiting pathogenic and spoilage microorganisms. Safety assessments and migration studies generally indicate compliance with established regulatory limits; however, concerns regarding chronic toxicity, nanoparticle bioaccumulation, environmental persistence, and human exposure remain important research priorities. International regulatory agencies including the U.S. Food and Drug Administration (FDA), European Food Safety Authority (EFSA), World Health Organization (WHO), and Food and Agriculture Organization (FAO) have developed nano‐specific safety assessment frameworks and risk evaluation guidelines. Regional regulations within the European Union, North America, and Asia‐Pacific increasingly emphasize traceability, labeling, migration testing, lifecycle analysis, and safe‐by‐design approaches for commercialization. Future research should prioritize standardized toxicological protocols, sustainable bio‐based nanomaterials, harmonized international regulations, advanced smart sensing integration, and consumer acceptance studies to ensure safe and scalable applications of nanotechnology in food systems.