Extended platelet rich fibrin versus allograft as a space filling material in immediate dental implant placement

BACKGROUND: Immediate implant has been one of the solutions to decrease bone resorption after tooth extraction. Gap distance between the dental implant and adjacent bone has undergone much research to enhance bone formation in this area. This is small exploratory study that aimed to compare the efficacy of extended platelet rich fibrin (e-PRF) a regenerative biomaterial produced by heating platelet-poor plasma (PPP) to denature albumin, extending the resorption time of standard PRF from 2 to 3 weeks to 4-6 months, as well as allograft as a space filling material in immediate dental implant placement. PATIENTS AND METHODS: Twenty-eight implants were placed for the prosthetic replacement of non-restorable single-rooted maxillary teeth using immediate implant placement. Patients were randomly allocated into two equal groups (n = 14 each). In Group I, allograft was placed in the peri-implant gap, whereas in Group II, e-PRF was used. Implant stability was assessed using resonance frequency analysis (RFA). Buccal bone thickness and marginal bone loss were evaluated using CBCT throughout the follow-up period. Statistical analysis was performed on all clinical and radiographic data. RESULTS: A total of 28 patients received 28 immediate implants in the maxillary esthetic zone. During the 12-month follow-up period, all implants were successful with no complications. No statistically significant differences were observed between the groups regarding implant stability, marginal bone loss, or buccal bone thickness. CONCLUSION: Within this small exploratory trial, no statistically significant intergroup differences were detected between e-PRF and allograft as space-filling materials around immediate implants regarding stability, marginal bone loss, and buccal bone thickness. TRIAL REGISTRATION: Clinical-Trials.gov PRS ( https://register. CLINICALTRIALS: gov ) has this study registered under the identifier number. NCT07445776 on 03/02/2026.