Treatment-resistant chronic urticaria associated with papillary thyroid carcinoma: a case report

BACKGROUND: Chronic idiopathic urticaria is a challenging condition that may require advanced therapies, such as omalizumab. Its association with malignancy, particularly papillary thyroid carcinoma, remains unclear and is rarely reported. CASE PRESENTATION: A 31-year-old Omani woman, with treatment-resistant idiopathic chronic urticaria requiring omalizumab for symptom control was subsequently diagnosed with papillary thyroid carcinoma. The patient underwent total thyroidectomy, after which she experienced partial remission of urticaria symptoms, including the longest symptom-free interval since disease onset. CONCLUSIONS: This case highlights a potential association between papillary thyroid carcinoma and chronic idiopathic urticaria, suggesting that evaluation for underlying malignancy may be considered in refractory cases.