Baseline plasma-informed circulating tumor DNA analyses comparing multiplex digital PCR and NGS for longitudinal monitoring in Hodgkin lymphoma
Despite excellent cure rates in Hodgkin lymphoma (HL) [ 1 ], 10–15% of patients experience primary treatment failure or long-term treatment-associated complications due to overtreatment [ 2 , 3 ]. Currently, interim positron emission tomography–computed tomography (PET/CT) with 18 F-fluorodeoxyglucose, after two chemotherapy cycles, guides therapy in advanced stage-disease [ 4 ]. However, PET/CT has limited specificity, resulting in frequent false-positive and occasional false-negative findings [ 5 ]. underscoring the need for sensitive molecular tools for treatment response assessment and detection of measurable residual disease (MRD).
Authors
- Tove Wästerlid (ORCID: https://orcid.org/0000-0002-4281-0349)
- Blaž Oder (ORCID: https://orcid.org/0000-0001-7984-3104)
- Emma Tham (ORCID: https://orcid.org/0000-0001-6079-164X)
- Richard Rosenquist (ORCID: https://orcid.org/0000-0002-0211-8788)
- O. I. Krynina (ORCID: https://orcid.org/0009-0006-6911-557X)
- Marzia Palma (ORCID: https://orcid.org/0000-0003-4287-3179)
- Lotta Hansson (ORCID: https://orcid.org/0000-0001-6614-5737)
- Irina Savitcheva (ORCID: https://orcid.org/0009-0000-8794-065X)
- Anna Gellerbring (ORCID: https://orcid.org/0009-0002-4505-2173)
- Mathias Johansson (ORCID: https://orcid.org/0000-0001-9433-3655)
- Leonie Saft (ORCID: https://orcid.org/0000-0002-4357-1570)
- Moa Hägglund (ORCID: https://orcid.org/0000-0003-3765-4342)
- Z. Haider (ORCID: https://orcid.org/0000-0002-0759-3932)
- Linn Deleskog Spångberg
- Karl Nyrén
- Karin E. Smedby
- Cecilia Jylhä
- Anna Lyander
- Emil Lundin
Institutions
- Karolinska University Hospital (SE)
- Heidelberg University (DE)
- Science for Life Laboratory (SE)
- University Hospital Heidelberg (DE)
- Karolinska Institutet (SE)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Blood Cancer Journal
- Published
- 2026-06-27
- DOI
- https://doi.org/10.1038/s41408-026-01555-2
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancerfonden
- Karolinska Institutet
- Kungliga Tekniska Högskolan
- Vetenskapsrådet
- Barncancerfonden
- Radiumhemmets Forskningsfonder
- Science for Life Laboratory