Comparative hemostatic efficacy of oxidized regenerated cellulose powder and fibrin glue in a rat model of induced liver parenchymal hemorrhage

The objective of this study is to compare the hemostatic efficacy of oxidised regenerated cellulose powder (Surgicel ® Powder) and fibrin glue (Tisseel ® ) in a rat model of liver parenchymal haemorrhage, and to evaluate their effects on tissue healing. Preoperative haemoglobin and haematocrit values were comparable among the groups ( p > 0.05). At 24 h, postoperative haemoglobin and haematocrit values differed significantly among the three groups ( p = 0.045 and p = 0.042, respectively), with lower values in the saline-compression control group and relatively preserved values in the Surgicel ® Powder and Tisseel ® groups. However, no statistically significant difference was identified between the two active treatment groups. Histopathological evaluation revealed no statistically significant between-group differences in necrosis, inflammation, fibrosis, haemorrhage, or granulation tissue formation ( p > 0.05).