Bioinspired Anisotropic Collagen-Based Conductive Hydrogels Promote Neuronal Differentiation via Activation of Mechanoelectrical Signaling
influx, and activate a mechanotransduction cascade involving the integrin-FAK signaling and Yes-associated protein (YAP) nuclear accumulation. Consequently, by utilizing the synergistic effects of aligned topologies, mechanical signals, and electrical stimuli to guide neuronal differentiation, we demonstrated the critical role of matrix microstructure in neuronal formation, as well as provided a platform for directing neural differentiation in vitro.
Authors
- Shuofeng Li (ORCID: https://orcid.org/0000-0002-6033-6476)
- Tie Wang (ORCID: https://orcid.org/0000-0001-5965-6520)
- Wei L
- Wenhai Lin (ORCID: https://orcid.org/0000-0003-4928-8183)
- Zhiyuan Wang (ORCID: https://orcid.org/0009-0000-2747-4570)
- Kunpeng Li (ORCID: https://orcid.org/0000-0003-1807-4545)
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-6352-6304)
- Shifang Wen
- Wei Zhang (ORCID: https://orcid.org/0009-0002-7260-0825)
- Meng Yu
Institutions
- Tianjin University of Technology (CN)
- Institute of Polymers (BG)
- Ingenierie des Materiaux polymeres (FR)
- Health & Life (Taiwan) (TW)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-06-27
- DOI
- https://doi.org/10.1021/acsabm.6c00574
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China