Protective Effect of Phytic Acid in Cardiovascular Diseases: A Systematic Review

ABSTRACT Cardiovascular diseases (CVDs) are a cluster of ailments that impact the heart and blood vessels and are a primary public health problem of mortality on a global scale. Phytic acid, a dietary constituent frequently present in foods like seeds, has been linked to many pharmacological attributes, including anti‐cancer, antioxidant, anti‐inflammatory, anti‐calcifying, and anti‐dyslipidemia effects. The objective of this study was to review the literature reporting the effects of the dietary component phytic acid on CVDs. We conducted a comprehensive analysis of both preclinical and clinical in vivo research on the use of phytic acid for managing CVDs. We assessed the risk of bias in these studies using the Syrcle and Revman methods. In this study, two investigators were involved. One investigator was assigned the task of assessing the data, while the other investigator was responsible for analyzing any contradictions. A total of eleven studies were chosen and verified. These studies suggest that phytic acid may have potential therapeutic effects on CVDs, particularly in preclinical models of cardiovascular calcification and myocardial ischemia.