APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update
Globally, especially in the Asia Pacific region, chronic hepatitis B infection has led to an undesirable escalating morbidity and mortality with acute-on chronic liver failure, end-staged liver cirrhosis, and hepatocellular carcinoma. This has happened despite the past four decades of major scientific advances made in screening methods, vaccination strategies, highly effective low-cost anti-viral therapies, and surveillance strategies for early detection of hepatocellular carcinoma. To address this health threat, APASL has formed a Viral Elimination Taskforce to unite key opinion leaders from its member countries and regions. The ongoing shifts in hepatitis B epidemiology, socioeconomic changes, and advancements in technology are taken into consideration. With the conjoint efforts of all the members of the APASL Viral Elimination Taskforce, these clinical practice guidelines have been formulated aiming to facilitate healthcare professionals, policy-makers, and patients in making practical and cost-effective management decisions for chronic hepatitis B infection. Altogether, it provides recommendations in 13 major areas related to screening, vaccination, treatment, and HCC surveillance. The implementation of these clinical practice guidelines represents major APASL effort toward elimination of the disease burden due to chronic hepatitis B infection in Asia Pacific region.
Authors
- 窦晓光
- Sang Hoon Ahn (ORCID: https://orcid.org/0000-0002-3629-4624)
- Rosmawati Mohamed
- Terry Cheuk‐Fung Yip (ORCID: https://orcid.org/0000-0002-1819-2464)
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Hasmik Ghazinian
- Tawesak Tanwandee (ORCID: https://orcid.org/0000-0001-7634-0843)
- Rinaldi Lesmana
- Shang‐Chin Huang (ORCID: https://orcid.org/0000-0003-2507-9627)
- Ching‐Lung Lai (ORCID: https://orcid.org/0000-0002-5927-2436)
- Yoon Jun Kim (ORCID: https://orcid.org/0000-0001-9141-7773)
- George K.K. Lau (ORCID: https://orcid.org/0000-0002-8928-3769)
- Pham Thanh Thuy
- Hong You (ORCID: https://orcid.org/0000-0002-8125-7961)
- Vincent Wai Sun Wong
- Grace Lai Hung Wong
- Rino Gani
- Zhiliang Gao
- Manal El-Sayed
- Diana Payawal
- Jidong Jia (ORCID: https://orcid.org/0000-0002-4673-8890)
- Guiqiang Wang
- Dong Ji
- Alexander Thompson
- Tatsuo Kanda
- Manoj Kumar Sharma
- Shiv Kumar Sarin
- Motoyuki Otsuka
- Jing Chen
- Masao Omata
- Jacob George
- Jinlin Hou
- Hui Zhuang
- Wenhong Zhang
- Jose D. Sollano
- Jian-Gao Fan
- Jia-Horng Kao
- George Goh
- Lai Wei
- Jian Sun
- Keo Sailey
- Saeed Hamid (ORCID: https://orcid.org/0000-0001-7218-6885)
- Kadir Dokmeci
- Necati Ormeci
- Ming-Lung Yu
- Eng Kiong Yeoh
- Rakhi Maiwall
- APASL Viral Elimination Taskforce
- Qin Ning
Institutions
- Ain Shams University (EG)
- Aga Khan University (PK)
- Bahçeşehir University (TR)
- Siriraj Hospital (TH)
- Seoul National University (KR)
- Kaohsiung Medical University (TW)
- Sun Yat-sen University (CN)
- Okayama University (JP)
- The University of Melbourne (AU)
- Chinese University of Hong Kong (HK)
- Ministry of Health (KH)
- Capital Medical University (CN)
- Yonsei University (KR)
- Millennium Institute (BR)
- Peking University (CN)
- Singapore General Hospital (SG)
- Fudan University (CN)
- XinHua Hospital (CN)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Chinese PLA General Hospital (CN)
- University of Indonesia (ID)
- José Rizal University (PH)
- St Vincent's Hospital Melbourne (AU)
- Center for Creative Initiatives in Health and Population (VN)
- Humanity & Health (CN)
- Nanfang Hospital (CN)
- University of Yamanashi Hospital (JP)
- Institute of Liver and Biliary Sciences (IN)
- Niigata University Medical and Dental Hospital (JP)
- Zhongshan Hospital (CN)
- Peking University First Hospital (CN)
- National Taiwan University Hospital (TW)
- Westmead Institute (AU)
- Westmead Institute for Medical Research (AU)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Beijing Friendship Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- Huashan Hospital (CN)
- Tongji Hospital (CN)
- Istanbul Health and Technology University
- Huazhong University of Science and Technology (CN)
- Istanbul Technical University (TR)
- Southern Medical University (CN)
- Yerevan State Medical University (AM)
- University of Santo Tomas (PH)
- National University of Malaysia (MY)
- University of Hong Kong (HK)
- China Medical University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Hepatology International
- Published
- 2026-06-27
- DOI
- https://doi.org/10.1007/s12072-026-11108-1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Imperial College London