Enantioselective Tropolone Diels-Alder Reaction with Alkynals

The enantioselective tropolone Diels–Alder reaction with alkynals was developed using Jørgensen-Hayashi catalysts. Series of highly functionalized bicyclo[3.2.2] ring structures were constructed in one step with good yield and up to 93% enantioselectivity. This opens up new avenues for future research on both tropolone Diels–Alder chemistry, and the iminium catalysis of ynals.

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Publication Details

Journal
Synlett
Published
2026-06-26
DOI
https://doi.org/10.1055/a-2903-2760
Primary Topic
Synthesis of Organic Compounds
Type
article
Field-Weighted Citation Impact
0.00

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article

Enantioselective Tropolone Diels-Alder Reaction with Alkynals

Pingfan Li, Shuzhong Zhao, Chunyang Su
Synlett
Synthesis of Organic Compounds
article

Enantioselective Tropolone Diels-Alder Reaction with Alkynals

Pingfan Li, Shuzhong Zhao, Chunyang Su
article en

Abstract

The enantioselective tropolone Diels–Alder reaction with alkynals was developed using Jørgensen-Hayashi catalysts. Series of highly functionalized bicyclo[3.2.2] ring structures were constructed in one step with good yield and up to 93% enantioselectivity. This opens up new avenues for future research on both tropolone Diels–Alder chemistry, and the iminium catalysis of ynals.

Synlett
Beijing University of Chemical Technology (CN)
National Key Research and Development Program of China
Openalex Percentile: Top 8%
Synthesis of Organic Compounds
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