Pleomorphic Lipoma of the Left Buccal Mucosa: Report of a Case with an Emphasis on its Differential Diagnoses

Lipomas are common benign mesenchymal tumors composed of mature adipocytes, typically found in subcutaneous tissues. While common in the head and neck region, their occurrence in the oral cavity, especially variants like pleomorphic lipoma, is exceedingly rare. Pleomorphic lipoma (PL) is a distinct histological subtype characterized by a mixture of mature adipocytes, spindle cells, rope-like collagen bundles, and classic "floret-like" multinucleated giant cells. Its clinical significance lies in its potential to mimic a well-differentiated liposarcoma, necessitating accurate histopathological diagnosis.We report a case of pleomorphic lipoma in a 33-year-old male who presented with a slowly growing, painless mass in his left buccal mucosa.This case highlights the rare occurrence of pleomorphic lipoma in the buccal mucosa, emphasizing the importance of thorough histopathological evaluation for accurate diagnosis and differentiation from malignant lesions.