Regioselective Hydroarylation of Ynamides: A Direct Synthetic Route to Trisubstituted Enamides
Trisubstituted enamides are commonly found in natural products, pharmaceuticals, and functional materials. A general method for synthesizing trisubstituted enamides is the hydroarylation of ynamides. A metal-free, atom-efficient, regioselective 1,2-hydroarylation of ynamides is herein demonstrated using an arene as a coupling partner. The reaction exhibits a broad substrate scope and tolerates ynamides derived from biologically relevant molecules, highlighting its synthetic utility. In addition, the hydroarylated products can be readily transformed into diverse functional molecules, demonstrating the versatility of this approach.
Authors
- Avijit Maity (ORCID: https://orcid.org/0009-0008-3972-8820)
- Manash Protim Gogoi (ORCID: https://orcid.org/0000-0002-4966-150X)
- Aradhana Sahoo (ORCID: https://orcid.org/0009-0001-1215-8222)
- Soumyashree Priyadarshinee
- Bishnu Prasad Lima (ORCID: https://orcid.org/0009-0005-6621-5383)
- Akhila K. Sahoo (ORCID: https://orcid.org/0000-0001-5570-4759)
Institutions
- National Institute of Science Education and Research (IN)
- University of Hyderabad (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-06-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c02382
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Council of Scientific and Industrial Research, India
- University Grants Commission
- University of Hyderabad
- Science and Engineering Research Board