How Common is Dysphagia After Anterior Cervical Spine Surgery, What Drives it, and Can it be Prevented? An Umbrella Review of Systematic Evidence

Study DesignUmbrella systematic review.ObjectiveTo critically appraise and synthesise the existing systematic review evidence regarding incidence, risk factors, management strategies, and prognostic impact of dysphagia in patients undergoing anterior cervical spine surgery(ACSS), with interpretation explicitly weighted by methodological confidence.MethodsA systematic search (inception-November 2025) of PubMed, Embase, Scopus, Web of Science, and the Cochrane Database identified systematic reviews and meta-analyses evaluating dysphagia after ACDF, ACCF, CDA, or multilevel ACSS. Two reviewers independently screened and extracted data. Methodological quality was appraised using AMSTAR-2. Findings were synthesised narratively at the umbrella level and interpreted proportionate to the confidence of evidence.ResultsThirty-two systematic reviews (>3.6 million patients) were included. Dysphagia incidence ranged from 1%-79% (variations largely driven by heterogeneous definitions and timepoints). Early postoperative (≤2 weeks) dysphagia was common (up to 71%); whereas persistent dysphagia (≥12 months) was reported in 12-14% in selected analyses. Female sex, multilevel procedures, C3-C4 involvement, anterior plating, and rhBMP-2 exposure were recurrently associated with increased risk. In contrast, zero-profile implants, cuff-pressure control, and perioperative steroids were associated with reduced early dysphagia in low-confidence reviews. However, 31/32 reviews were rated critically low confidence by AMSTAR-2 grading, limiting certainty. Only one RCT-based steroid meta-analysis achieved low confidence.ConclusionDysphagia is frequently reported following ACSS, particularly in the early postoperative period. No preventive or therapeutic strategy can currently be recommended as standard of care based on high-certainty evidence. Most findings remain hypothesis-generating and require validation in high-quality prospective studies.

Authors

Institutions

Publication Details

Journal
Global Spine Journal
Published
2026-06-26
DOI
https://doi.org/10.1177/21925682261462860
Primary Topic
Cervical and Thoracic Myelopathy
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

How Common is Dysphagia After Anterior Cervical Spine Surgery, What Drives it, and Can it be Prevented? An Umbrella Review of Systematic Evidence

Khan Sharun, Sathish Muthu, Sakthivel Rajan Rajaram Manoharan, Satish Kumar Rajappan Chandra et al.
Global Spine Journal
Cervical and Thoracic Myelopathy
article

How Common is Dysphagia After Anterior Cervical Spine Surgery, What Drives it, and Can it be Prevented? An Umbrella Review of Systematic Evidence

Khan Sharun, Sathish Muthu, Sakthivel Rajan Rajaram Manoharan, Satish Kumar Rajappan Chandra, Vibhu Krishnan Viswanathan, Dhibin Vikash Kolarpatti Ponnusamy, Steven Theiss, Venkatesh Subramanian
article en

Abstract

Study DesignUmbrella systematic review.ObjectiveTo critically appraise and synthesise the existing systematic review evidence regarding incidence, risk factors, management strategies, and prognostic impact of dysphagia in patients undergoing anterior cervical spine surgery(ACSS), with interpretation explicitly weighted by methodological confidence.MethodsA systematic search (inception-November 2025) of PubMed, Embase, Scopus, Web of Science, and the Cochrane Database identified systematic reviews and meta-analyses evaluating dysphagia after ACDF, ACCF, CDA, or multilevel ACSS. Two reviewers independently screened and extracted data. Methodological quality was appraised using AMSTAR-2. Findings were synthesised narratively at the umbrella level and interpreted proportionate to the confidence of evidence.ResultsThirty-two systematic reviews (>3.6 million patients) were included. Dysphagia incidence ranged from 1%-79% (variations largely driven by heterogeneous definitions and timepoints). Early postoperative (≤2 weeks) dysphagia was common (up to 71%); whereas persistent dysphagia (≥12 months) was reported in 12-14% in selected analyses. Female sex, multilevel procedures, C3-C4 involvement, anterior plating, and rhBMP-2 exposure were recurrently associated with increased risk. In contrast, zero-profile implants, cuff-pressure control, and perioperative steroids were associated with reduced early dysphagia in low-confidence reviews. However, 31/32 reviews were rated critically low confidence by AMSTAR-2 grading, limiting certainty. Only one RCT-based steroid meta-analysis achieved low confidence.ConclusionDysphagia is frequently reported following ACSS, particularly in the early postoperative period. No preventive or therapeutic strategy can currently be recommended as standard of care based on high-certainty evidence. Most findings remain hypothesis-generating and require validation in high-quality prospective studies.

Global Spine Journal
SRM Institute of Science and Technology (IN), University of Alabama (US), Vinayaka Missions University (IN), Yuan Ze University (TW)
Good health and well-being
Openalex Percentile: Top 5%
Cervical and Thoracic Myelopathy
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.