Acquired haemophilia A diagnosed during preoperative evaluation for lung cancer surgery: A case report

Acquired haemophilia A is a severe and rare coagulation disorder caused by autoantibodies (inhibitors) against factor VIII. We present a case of acquired haemophilia A diagnosed during preoperative evaluation for lung tumour resection. Laboratory evaluation showed prolonged activated partial thromboplastin time (aPTT), reduced factor VIII activity, and detectable factor VIII inhibitors. Immunosuppressive therapy with oral prednisone led to normalisation of coagulation parameters and elimination of factor VIII inhibitors within 4 weeks. Surgical resection was performed without haemorrhagic complications. This case highlights the importance of early diagnosis and timely intervention in acquired haemophilia A to enhance clinical outcomes and mitigate the risk of haemorrhagic complications. Late identification of the disorder can have potentially catastrophic consequences in patients undergoing thoracic surgery.