Long-Term Follow-Up of JCOG1008, a Randomized Phase II/III Trial of Chemoradiotherapy Comparing 3-Weekly Cisplatin With Weekly Cisplatin in Postoperative Head and Neck Cancer
The interim analysis of JCOG1008 demonstrated that chemoradiotherapy with cisplatin 40 mg/m 2 once a week for seven cycles (weekly cisplatin) was noninferior in terms of overall survival (OS) compared with chemoradiotherapy with cisplatin 100 mg/m 2 once every 3 weeks for three cycles (3-weekly cisplatin) for postoperative high-risk locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). This report presents the long-term follow-up results of JCOG1008. In this phase II/III trial, patients with postoperative high-risk LA-SCCHN were randomly assigned to receive either chemoradiotherapy with 3-weekly cisplatin or with weekly cisplatin. A total of 261 patients were enrolled. At the final analysis, with a median follow-up of 5.6 years, 5-year OS was 58.7% in the 3-weekly arm and 71.2% in the weekly arm (hazard ratio, 0.76 [95% CI, 0.52 to 1.12 [<1.32]]), confirming the noninferiority of the weekly regimen. Both 5-year relapse-free survival (RFS) and 5-year local RFS were numerically better in the weekly arm. No late adverse event showed more than a 10% difference between the two arms. In conclusion, 5-year follow-up confirmed that chemoradiotherapy with weekly cisplatin is noninferior in OS to chemoradiotherapy with 3-weekly cisplatin in patients with postoperative high-risk LA-SCCHN. These results further support the use of weekly cisplatin plus radiotherapy as a reasonable alternative for this patient population.
Authors
- Akira Ohkoshi (ORCID: https://orcid.org/0000-0003-0652-7041)
- Yo Kishimoto (ORCID: https://orcid.org/0000-0002-3583-0165)
- Kiyoto Shiga (ORCID: https://orcid.org/0000-0002-7461-1352)
- Makoto Tahara (ORCID: https://orcid.org/0000-0001-9035-3106)
- Naoki Nishio (ORCID: https://orcid.org/0000-0003-1495-0376)
- Yukinori Asada (ORCID: https://orcid.org/0000-0002-8955-7168)
- Yasushi Fujimoto (ORCID: https://orcid.org/0000-0002-6044-686X)
- Seiichi Yoshimoto (ORCID: https://orcid.org/0000-0001-9270-095X)
- Naomi Kiyota (ORCID: https://orcid.org/0000-0001-8021-6116)
- Nobuhiko Oridate (ORCID: https://orcid.org/0000-0002-6968-3028)
- Eiji Shimura
- Shujiro Minami (ORCID: https://orcid.org/0000-0002-7992-4868)
- Junki Mizusawa (ORCID: https://orcid.org/0000-0001-8123-5298)
- Nobuhiro Hanai (ORCID: https://orcid.org/0000-0003-2524-8283)
- Yuji Hirayama
- Yuki Saito (ORCID: https://orcid.org/0000-0002-4825-7783)
- Masato Nagaoka (ORCID: https://orcid.org/0000-0001-6350-5186)
- Nobuya Monden (ORCID: https://orcid.org/0000-0002-1119-028X)
- Takenori Ogawa (ORCID: https://orcid.org/0000-0003-1556-7328)
- Kenji Okami (ORCID: https://orcid.org/0000-0003-4228-3347)
- Hiroki Hara (ORCID: https://orcid.org/0000-0003-3881-9815)
- Ryuichi Hayashi (ORCID: https://orcid.org/0000-0002-4889-4539)
- Shigeyuki Murono (ORCID: https://orcid.org/0000-0002-0544-9590)
- Takahiro Asakage
- Takeshi Kodaira (ORCID: https://orcid.org/0000-0002-7075-8488)
- SHUJIRO MINAMI
- Shigemichi Iwae (ORCID: https://orcid.org/0000-0003-4011-6633)
- Akihiro Homma (ORCID: https://orcid.org/0000-0003-1488-0646)
- Yusuke Onozawa (ORCID: https://orcid.org/0009-0003-1019-7564)
- Ichiro Ota (ORCID: https://orcid.org/0000-0003-3815-8877)
- K. Katagiri (ORCID: https://orcid.org/0000-0002-6436-2559)
- Tsutomu Ueda (ORCID: https://orcid.org/0000-0001-9771-3880)
- Mizuo Ando (ORCID: https://orcid.org/0000-0002-0754-2545)
- Masashi Sugasawa
- Tomoko Yamazaki
- Kazuhiko Nakagawa (ORCID: https://orcid.org/0000-0003-1284-9776)
- Kenichi Nakamura (ORCID: https://orcid.org/0000-0003-3534-8296)
- Kaoru Tanaka (ORCID: https://orcid.org/0000-0002-4927-1368)
- Hiroshi Nishino (ORCID: https://orcid.org/0000-0001-6236-8167)
- Hirokazu Uemura (ORCID: https://orcid.org/0000-0001-7502-3619)
- Hiroki Mitani
- Koichi Omori
- Takashi Fujii
- Hiroshi Nishino
- Akihiro Homma
- Tsutomu Ueda
- Hiroki Hara
- Makoto Tahara
- Naomi Kiyota
Institutions
- Jikei University School of Medicine (JP)
- Tokai University (JP)
- Jichi Medical University (JP)
- Iwate Medical University (JP)
- Kyoto University (JP)
- Shizuoka Cancer Center (JP)
- Kobe University Hospital (JP)
- Nagoya University Hospital (JP)
- Tohoku University Hospital (JP)
- Tokyo Medical Center (JP)
- Yokohama City University Hospital (JP)
- Miyagi Prefectural Hospital Organization (JP)
- University of Tokyo Hospital (JP)
- Kindai University Sakai Hospital (JP)
- Saitama Cancer Center (JP)
- Hiroshima University Hospital (JP)
- Aichi Cancer Center (JP)
- The Cancer Institute Hospital (JP)
- Shikoku Cancer Center (JP)
- Hokkaido University Hospital (JP)
- National Cancer Center Hospital East (JP)
- Fukushima Medical University Hospital (JP)
- Japan Clinical Cancer Research Organization (JP)
- Osaka International Cancer Institute (JP)
- Jichi Medical University Hospital (JP)
- Tokyo National Hospital (JP)
- Hyogo Prefectural Cancer Center (JP)
- Nara Medical University (JP)
- Saitama Medical University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-06-26
- DOI
- https://doi.org/10.1200/jco-25-01708
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development