Relationship Between Patient State Index and Richmond Agitation Sedation Scale for Sedation in Critically Ill Patients: An Observational Analytical Study

Objective: The objective of this study was to find the relationship between Patient State Index (PSI) and Richmond Agitation Sedation Scale (RASS) for sedation in critically ill patients. Methods: < 0.05 was considered significant. Results: < 0.001) which dropped to 0.786 with repeated measures correlation. The sensitivity and specificity were 88.66% and 88.57%, respectively, with an area under the receiver operating characteristic curve of 0.947; these improved to 100% and an area under the curve of 1 when analysed per patient. To maintain RASS between 0 and -3, the PSI cutoff was found to be 50-52. Conclusion: PSI correlates well with RASS across sedation regimens in critically ill patients and assists in monitoring of sedation. Adequate sedation to reach an RASS of 0 to -3 may be achieved at a PSI of 50-52. However, these findings are preliminary and require validation in larger cohorts.