A Review Article on Alzheimer's disease (AD): Current Landscape in Treatment Research for Alzheimer's disease

ABSTRACT:Alzheimer 's disease (AD) is a progressive Neurodegenerative disorder characterized bycognitive decline, memory loss and functional impairment. AD is a complex multifactorialdisorder, influenced by both genetic and environmental factors. It is the most common causeof dementia globally and is clinically characterized by a progression from episodic memoryproblems to a slow general decline of cognitive function, our current understanding of ADpathologies involves various hypotheses such as cholinergic, amyloid, tau protein,Inflammatory, oxidative stress, metal ion, glutamate excitoxicity, microbiota-gut-brain axis,and abnormal autophagy and detailed information on signalling pathways linked to ADpathogenesis. This review mainly highlights the aetiology, clinical features, diagnosis andtreatment (pharmacological & non-pharmacological therapies) of people with Alzheimer'sdisease and also focussed on current Landscape in treatment Research for AD, Alzheimer'sDeng Development pipeline 2024. Key words:Alzheimer’s disease, Dementia, Neurodegenerative, cognitive function, signalling pathways,Landscape, Genetic and Environmental.