Persistent Bilateral Palmar Hyperkeratotic Papules in an Adolescent Male

A 14-year-old boy presented with a more than 3-year history of mildly pruritic keratotic papules on both palms, resembling punctate palmoplantar keratoderma, porokeratotic eccrine ostial and dermal duct naevus, and Darier disease. Lesions showed central depressions, brown keratin plugs and whitish collarettes. Histopathology revealed epidermal thinning, a diminished granular layer, basal vacuolar alteration, and a dense lymphohistiocytic infiltrate confined to widened dermal papillae embraced by adjacent rete ridges, forming a “claw clutching a ball” configuration.

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Publication Details

Journal
Clinical and Experimental Dermatology
Published
2026-06-25
DOI
https://doi.org/10.1093/ced/llag276
Primary Topic
Genetic and rare skin diseases.
Type
article
Field-Weighted Citation Impact
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article

Persistent Bilateral Palmar Hyperkeratotic Papules in an Adolescent Male

Shuyao He, Xulei Huang, Yao Lu, Xinyi Jing
Clinical and Experimental Dermatology
Genetic and rare skin diseases.
article

Persistent Bilateral Palmar Hyperkeratotic Papules in an Adolescent Male

Shuyao He, Xulei Huang, Yao Lu, Xinyi Jing
article en

Abstract

A 14-year-old boy presented with a more than 3-year history of mildly pruritic keratotic papules on both palms, resembling punctate palmoplantar keratoderma, porokeratotic eccrine ostial and dermal duct naevus, and Darier disease. Lesions showed central depressions, brown keratin plugs and whitish collarettes. Histopathology revealed epidermal thinning, a diminished granular layer, basal vacuolar alteration, and a dense lymphohistiocytic infiltrate confined to widened dermal papillae embraced by adjacent rete ridges, forming a “claw clutching a ball” configuration.

Clinical and Experimental Dermatology
Chengdu Women's and Children's Central Hospital (CN)
Openalex Percentile: Top 7%
Genetic and rare skin diseases.
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Persistent Bilateral Palmar Hyperkeratotic Papules in an Adolescent Male — Shuyao He, Xulei Huang, et al. · Clinical and Experimental Dermatology (2026) | TGRS Research Map | TGRS