Clinical application of antidepressants: Advantages and opportunities for individual drugs

Antidepressants rank among the most frequently prescribed medications globally, a trend attributed to their efficacy in managing major depressive disorder, other forms of depressive states, anxiety disorders, and various mental health conditions. Furthermore, antidepressants demonstrate several non-psychotropic pharmacological effects, which broaden their potential applications beyond psychiatry into general medical practice. This article presents essential information regarding the pharmacological spectrum, effectiveness, and safety profiles of diverse antidepressants, with a particular focus on escitalopram, duloxetine, and mirtazapine.

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Publication Details

Journal
S S Korsakov Journal of Neurology and Psychiatry
Published
2026-06-26
DOI
https://doi.org/10.17116/jnevro202612606145
Primary Topic
Treatment of Major Depression
Type
article
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article

Clinical application of antidepressants: Advantages and opportunities for individual drugs

Yury P. Sivolap, Владимир D. Mendelevich
S S Korsakov Journal of Neurology and Psychiatry
Treatment of Major Depression
article

Clinical application of antidepressants: Advantages and opportunities for individual drugs

Yury P. Sivolap, Владимир D. Mendelevich
article en

Abstract

Antidepressants rank among the most frequently prescribed medications globally, a trend attributed to their efficacy in managing major depressive disorder, other forms of depressive states, anxiety disorders, and various mental health conditions. Furthermore, antidepressants demonstrate several non-psychotropic pharmacological effects, which broaden their potential applications beyond psychiatry into general medical practice. This article presents essential information regarding the pharmacological spectrum, effectiveness, and safety profiles of diverse antidepressants, with a particular focus on escitalopram, duloxetine, and mirtazapine.

S S Korsakov Journal of Neurology and PsychiatryVol. 126(6)
Peoples' Friendship University of Russia (RU), Kazan State Medical University (RU)
Good health and well-being
Openalex Percentile: Top 9%
Treatment of Major Depression
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