Dfpenicimeroterpenoid A, Meroterpenoids with 6/6/6/4/5 Polycyclic Skeletons from the Marine-Derived Fungus <i>Penicillium</i> sp. DF71
A novel andrastin-type meroterpenoid, dfpenicimeroterpenoid A ( 1 ), featuring an unprecedented fused 6/6/6/4/5 pentacyclic skeleton is described, along with four new analogues from marine-derived fungus Penicillium sp. DF71. The structures were established by analysis of their spectroscopic data, single-crystal X-ray diffraction, and quantum chemical calculations of electronic circular dichroism spectra. Compound 2 showed significant pro-angiogenic activity at a concentration of 20 μM, based on a zebrafish model. Furthermore, a plausible biosynthetic pathway for 1 is proposed.
Authors
- P. Li
- Jianhua Ju (ORCID: https://orcid.org/0000-0001-7712-8027)
- C B Liu
- Junying Ma (ORCID: https://orcid.org/0000-0002-0641-7291)
- Liwu Lin
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
Institutions
- Qilu University of Technology (CN)
- Shandong University (CN)
- Institute of Oceanology (CN)
- South China Sea Institute Of Oceanology (CN)
- Shandong Academy of Sciences (CN)
- Institute of Oceanology (BG)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-06-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c01506
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- South China Sea Institute of Oceanology, Chinese Academy of Sciences
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province