Electrooxidative Iodination of Carbonyl Compounds: A Mild, Simple, and Scalable Access to α‐Iodocarbonyls

A general method for α‐iodination of carbonyl compounds has been developed based on electrochemical generation of reactive electrophilic iodine species under mild reaction conditions. This work comprises quaternary ammonium salt as a stable and inexpensive iodine source. By employing electric current as a controllable and traceless alternative oxidant, our work eliminates the use of wasteful oxidants and hazardous reaction conditions. Thus, it demonstrates excellent tolerance toward oxidation‐sensitive substrates featuring aldehydes and heterocycles. Additionally, the reaction can be scaled up upon the introduction of a continuous flow setup.