Two-Stage Stochastic Integrated Product and Process Design for Conceptual Design of Flexible Sustainable Production Plants

High Resolution Image Download MS PowerPoint Slide As the chemical industry transitions toward sustainable production, integrated product and process design emerges as a vital task to improve resource and cost efficiency. However, current product and process design approaches typically fall short of flexibility considerations to address prevailing uncertainties during plant operation. We propose a two-stage stochastic programming (TSP) formulation for integrated product and process design, demonstrated on hybrid biorefineries for renewable fuel production. First-stage process design decisions are coupled with second-stage recourse decisions on feedstock selection, product formulation, and process operation; the uncertain variables pertain to key economic parameters and renewable feedstock availability. Compared to the deterministic benchmark, the TSP results in different chemical pathway selection and sizing with enhanced flexibility toward uncertainty in feedstock and energy supply, as well as product demand, 9% higher expected profits, and reduced fluctuations in production rate. In addition, the flexible process maintains economic viability in unfavorable scenarios where nominal designs incur losses. These findings underscore how decision-making in the early stages of process development benefits from uncertainty and flexibility considerations.

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Publication Details

Journal
Industrial & Engineering Chemistry Research
Published
2026-06-25
DOI
https://doi.org/10.1021/acs.iecr.6c00908
Primary Topic
Process Optimization and Integration
Type
article
Field-Weighted Citation Impact
0.00

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article

Two-Stage Stochastic Integrated Product and Process Design for Conceptual Design of Flexible Sustainable Production Plants

Alexander Mitsos, Manuel Dahmen, Bo Li, Marian Panofen et al.
Industrial & Engineering Chemistry Research
Process Optimization and Integration
article

Two-Stage Stochastic Integrated Product and Process Design for Conceptual Design of Flexible Sustainable Production Plants

Alexander Mitsos, Manuel Dahmen, Bo Li, Marian Panofen, Jakob Hoch
article en

Abstract

High Resolution Image Download MS PowerPoint Slide As the chemical industry transitions toward sustainable production, integrated product and process design emerges as a vital task to improve resource and cost efficiency. However, current product and process design approaches typically fall short of flexibility considerations to address prevailing uncertainties during plant operation. We propose a two-stage stochastic programming (TSP) formulation for integrated product and process design, demonstrated on hybrid biorefineries for renewable fuel production. First-stage process design decisions are coupled with second-stage recourse decisions on feedstock selection, product formulation, and process operation; the uncertain variables pertain to key economic parameters and renewable feedstock availability. Compared to the deterministic benchmark, the TSP results in different chemical pathway selection and sizing with enhanced flexibility toward uncertainty in feedstock and energy supply, as well as product demand, 9% higher expected profits, and reduced fluctuations in production rate. In addition, the flexible process maintains economic viability in unfavorable scenarios where nominal designs incur losses. These findings underscore how decision-making in the early stages of process development benefits from uncertainty and flexibility considerations.

Industrial & Engineering Chemistry Research
Forschungszentrum Jülich (DE), Jülich Aachen Research Alliance (DE), RWTH Aachen University (DE)
Helmholtz-Gemeinschaft, Deutsche Forschungsgemeinschaft
Openalex Percentile: Top 7%
Process Optimization and Integration
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Two-Stage Stochastic Integrated Product and Process Design for Conceptual Design of Flexible Sustainable Production Plants — Alexander Mitsos, Manuel Dahmen, et al. · Industrial & Engineering Chemistry Research (2026) | TGRS Research Map | TGRS