Studies toward Total Synthesis of Cipadonoid A and Harpertrioate A via Radical Cyclization
The highly congested fused tetracyclic core of cipadonoid A and harpertrioate A has been constructed using visible-light photoredox-catalyzed intramolecular Giese-type radical cyclization as a key step. The developed chemistry paves the way for the total synthesis of this family of biologically important natural products.
Authors
- Ying‐Tong Di (ORCID: https://orcid.org/0000-0001-5766-0198)
- Lei Xu (ORCID: https://orcid.org/0009-0003-5511-5622)
- Xiao‐Jiang Hao (ORCID: https://orcid.org/0000-0001-9496-2152)
- Xin‐Yu Tan (ORCID: https://orcid.org/0009-0002-1712-5128)
- Hong Liang (ORCID: https://orcid.org/0000-0002-0579-8651)
- Zhen Jun Yang (ORCID: https://orcid.org/0000-0001-8036-934X)
- Zhongchao Zhang (ORCID: https://orcid.org/0000-0001-5017-5691)
- zj Song
- Hao‐Jing Zang
- Xiao Ding
Institutions
- Nanjing Agricultural University (CN)
- Academy of Medical Sciences (GB)
- Kunming Institute of Botany (CN)
- Kunming University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Shenzhen Bay Laboratory (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Peking University Shenzhen Hospital (CN)
- State Key Laboratory of Chemical Engineering (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-06-25
- DOI
- https://doi.org/10.1021/acs.joc.6c00753
- Primary Topic
- Biological Activity of Diterpenoids and Biflavonoids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Natural Science Foundation of Guangdong Province
- Chinese Academy of Medical Sciences
- Yunnan Key Research and Development Program
- Shenzhen Fundamental Research Program
- Shenzhen-Hong Kong Institute of Brain Science
- Shenzhen Bay Laboratory