Microbiome-driven alterations in tryptophan metabolism contribute to behavioral comorbidities in the Muc2 knockout mouse model of chronic colitis
. Although early-life nutrient supplementation partially restored colonic tryptophan, it failed to fully rescue behavioral outcomes. Collectively, these findings demonstrate that chronic colitis is associated with microbiome-mediated disruption of host tryptophan metabolism, which correlates with neurobehavioral dysfunction. Targeting microbiome-driven metabolic alterations may represent a therapeutic strategy for both intestinal and neurobehavioral manifestations of IBD.
Authors
- Jacqueline A. Barnett (ORCID: https://orcid.org/0000-0001-6924-3674)
- Susan J. Murch (ORCID: https://orcid.org/0000-0001-5803-9483)
- Deanna L. Gibson (ORCID: https://orcid.org/0000-0003-0052-7550)
- Emad Yuzbashian (ORCID: https://orcid.org/0000-0002-1748-5978)
- Andis Klegeris (ORCID: https://orcid.org/0000-0001-6587-6458)
- Keith A. Sharkey (ORCID: https://orcid.org/0000-0001-9560-1711)
- Andrea Verdugo‐Meza (ORCID: https://orcid.org/0000-0001-9097-4965)
- Jessica Josephson (ORCID: https://orcid.org/0000-0003-2216-376X)
- Tyler J. Wenzel
Institutions
- Allen Institute for Brain Science (US)
- University of British Columbia (CA)
- University of Saskatchewan (CA)
Publication Details
- Journal
- Gut Microbes
- Published
- 2026-06-24
- DOI
- https://doi.org/10.1080/19490976.2026.2689121
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00