Volume‐Stable Collagen Matrix With or Without Platelet‐Rich Fibrin Impregnation for Multiple Gingival Recessions: A Randomized Clinical Trial

AIM: This split-mouth randomized clinical trial aimed to assess whether incorporating platelet-rich fibrin (PRF) into a volume-stable collagen matrix results in superior reduction of recession depth after 6 months of healing in the treatment of multiple gingival recessions using the coronally advanced flap. METHODS: Patients with bilateral maxillary RT1 recessions at non-molar sites were recruited. Each side received either a PRF-impregnated matrix or a non-impregnated matrix. Clinical parameters, including recession depth, keratinized tissue width, bleeding on probing, probing depth, clinical attachment level, and gingival thickness, were measured at baseline and 6 months, as well as the Root Coverage Esthetic Score (RES) and patient-reported outcome measures (PROMs). The percentage of complete root coverage was calculated 6 months after treatment. RESULTS: Twenty-five patients were enrolled. However, one patient was excluded due to incomplete follow-up. Both groups significantly improved over time, but no intergroup differences were observed for any of the clinical parameters (p > 0.05). No statistically significant differences were found between test and control groups in evaluations of RES and PROMs, showing similar postoperative experiences of patients. CONCLUSION: Within the limitations of this study, adding PRF to a volume-stable collagen matrix did not result in superior recession depth reduction or improved clinical, esthetic, or patient-reported outcomes after 6 months. TRIAL REGISTRATION: Brazilian Register of Clinical Trials (ensaiosclinicos.gov.br) identifier: RBR-3hqrvrr (20/10/2021).