A Catalyst-Free Three-Component Approach to Sulfonated Indole-Fused Diazepinones via SO <sub>2</sub> Insertion
A green, efficient, and environmentally benign synthetic strategy has been established for the preparation of diverse sulfonated indole-fused 1,4-diazepinones via catalyst-free multicomponent radical annulation. Notably, this radical cyclization also provides direct access to sulfonated indole-fused seven-membered diazepinones. The protocol features mild conditions, broad substrate scope, high yields (up to >99%), and excellent diastereoselectivity (up to >20:1 dr).
Authors
- 洪兆国
- M Zhang (ORCID: https://orcid.org/0009-0005-4652-6918)
- Jiapian Huang (ORCID: https://orcid.org/0000-0002-7463-1572)
- Jie Wu (ORCID: https://orcid.org/0000-0002-0967-6360)
- Jiayi Jiang
- Nianhua Luo (ORCID: https://orcid.org/0000-0002-0233-849X)
- Jian‐Qiang Chen (ORCID: https://orcid.org/0000-0001-8144-9069)
- Wei Xiao
- Shuping Huang
- Bichuan Wang
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Gannan Medical University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-06-25
- DOI
- https://doi.org/10.1021/acs.joc.6c00829
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00