Meroterpenoids Isolated from <i>Avicennia marina</i> Fruit Fungal Strain Aspergillus sp.
High Resolution Image Download MS PowerPoint Slide 3 new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes R -T ( 1 – 3 ), one new natural product ( 9 ), and six known compounds ( 4–8 and 10 ), were obtained from Avicennia marina (Forssk.) Vierh. fruit fungal strain Aspergillus sp. YLNU-Q11. These new compounds’ structures were elucidated using spectroscopic analyses, NMR/DP4+ calculations, and ECD studies. In the acetylcholinesterase (AChE) inhibitory assay, compound 8 showed moderate inhibitory activity (IC 50 = 9.54 μM). Further molecular docking analysis suggested that hydrogen bonding interactions with residues TYR374, GLY79, and GLY150 are crucial for the binding of 8 to AChE.
Authors
- Fan‐Fan Wang (ORCID: https://orcid.org/0000-0002-4959-209X)
- Jiwen Wu
- Pingfang Tao
- Zhongqing Wen
- Xiaoxia Liu (ORCID: https://orcid.org/0000-0002-3260-2343)
- Feng Qin (ORCID: https://orcid.org/0009-0003-9396-5986)
- Jingjing Tao (ORCID: https://orcid.org/0000-0002-0273-6535)
- Li-Ping Mo
- Xin-Xiu Nong
- Xuefeng Jin
Institutions
- Guangxi University (CN)
- Yulin Normal University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-06-25
- DOI
- https://doi.org/10.1021/acsomega.5c12372
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region