Fosfomycin (Contepo) for Complicated Urinary Tract Infections

The FDA has approved an IV formulation of the epoxide antibacterial drug fosfomycin (Contepo – Meitheal) for treatment of adults with complicated urinary tract infections (cUTIs) caused by susceptible isolates of Escherichia coli or Klebsiella pneumoniae. Oral fosfomycin has been available in the US for years for treatment of uncomplicated urinary tract infections. IV fosfomycin has been available in other countries for decades.