Fatal Tuberculous Meningitis With Hydrocephalus and SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion) in an Immunocompetent Adult With Miliary Tuberculosis: Diagnostic Challenges Associated With Language Barriers

Tuberculous meningitis is a severe manifestation of disseminated tuberculosis associated with high morbidity and mortality. I report the case of a 30-year-old previously healthy immunocompetent immigrant who initially presented with fever, malaise, and rhinorrhoea. A significant language barrier limited history-taking, contributing to diagnostic delay. His condition rapidly progressed to acute hydrocephalus and syndrome of inappropriate antidiuretic hormone secretion (SIADH) in the context of concomitant miliary pulmonary tuberculosis. Despite prompt initiation of anti-tubercular therapy, high-dose corticosteroids, and neurosurgical intervention, his neurological status deteriorated, and he succumbed within a short period. This case highlights the importance of early recognition of tuberculous meningitis and its potentially life-threatening complications, particularly among patients from tuberculosis-endemic regions where the disease remains prevalent. It also underscores how communication barriers in healthcare may delay diagnosis and worsen outcomes, especially in countries like the United Kingdom, where tuberculosis is relatively uncommon.

Authors

Publication Details

Journal
Cureus
Published
2026-06-25
DOI
https://doi.org/10.7759/cureus.111487
Primary Topic
Infectious Diseases and Tuberculosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Fatal Tuberculous Meningitis With Hydrocephalus and SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion) in an Immunocompetent Adult With Miliary Tuberculosis: Diagnostic Challenges Associated With Language Barriers

Priyanta Banerjee
Cureus
Infectious Diseases and Tuberculosis
article

Fatal Tuberculous Meningitis With Hydrocephalus and SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion) in an Immunocompetent Adult With Miliary Tuberculosis: Diagnostic Challenges Associated With Language Barriers

Priyanta Banerjee
article en

Abstract

Tuberculous meningitis is a severe manifestation of disseminated tuberculosis associated with high morbidity and mortality. I report the case of a 30-year-old previously healthy immunocompetent immigrant who initially presented with fever, malaise, and rhinorrhoea. A significant language barrier limited history-taking, contributing to diagnostic delay. His condition rapidly progressed to acute hydrocephalus and syndrome of inappropriate antidiuretic hormone secretion (SIADH) in the context of concomitant miliary pulmonary tuberculosis. Despite prompt initiation of anti-tubercular therapy, high-dose corticosteroids, and neurosurgical intervention, his neurological status deteriorated, and he succumbed within a short period. This case highlights the importance of early recognition of tuberculous meningitis and its potentially life-threatening complications, particularly among patients from tuberculosis-endemic regions where the disease remains prevalent. It also underscores how communication barriers in healthcare may delay diagnosis and worsen outcomes, especially in countries like the United Kingdom, where tuberculosis is relatively uncommon.

Cureus
Good health and well-being
Openalex Percentile: Top 6%
Infectious Diseases and Tuberculosis
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